A Rare Presentation of Gastric Signet Ring Cells: Signet Ring
Cell Lymphoma
Published: December 1, 2014 | DOI: https://doi.org/10.7860/JCDR/2014/.5323
Sithara Venkateshwar, Thomas Alexander, Moses Ambroise, Renu G’Boy Varghese, Anita Ramdas
1. Post Graduate, Department of Pathology, Pondicherry Institute of Medical Sciences, Ganapathychettikulam, Kalapet, Pondicherry, India.
2. Professor, Department of Gastroenterology, Pondicherry Institute of Medical Sciences, Ganapathychettikulam, Kalapet, Pondicherry, India.
3. Assistant Professor, Department of Pathology, Pondicherry Institute of Medical Sciences, Ganapathychettikulam, Kalapet, Pondicherry, India.
4. Professor and Head of Department, Department of Pathology, Pondicherry Institute of Medical Sciences, Ganapathychettikulam, Kalapet, Pondicherry, India.
5. Professor, Department of Pathology, Pondicherry Institute of Medical Sciences, Ganapathychettikulam, Kalapet, Pondicherry, India.
Correspondence
Dr. Sithara Venkateshwar,
Pondicherry Institute of Medical Sciences, Ganapathychettikulam, Kalapet, Pondicherry-605014, India.
Phone: 9176626410, E-mail: sitharavenkateshwar@gmail.com
We herewith present a rare and interesting case of gastric signet ring cell lymphoma (SRCL) in a 40-year-old retroviral positive lady. SRCL is a rare morphological variant of nodal lymphomas.Biopsy from the suspected lesion in the stomach showed diffuse sheets of cells with a large central vacuole displacing the nucleus to the periphery of the cell, imparting signet ring cell morphology. Negative reaction to PAS (Periodic acid Schiff) stain and subsequent strong positivity for the immunohistochemical markers such as CD45 (Leucocyte commonantigen) and CD20, a B-cell marker helped us to arrive at a diagnosis of signet ring B- cell lymphoma.
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